A recent study reveals that people who stop using popular slimming jabs like semaglutide or tirzepatide may regain lost weight far faster than those who stop conventional lifestyle regimens.
Research printed in a leading medical journal points out that while overweight people often shed about a fifth of their total mass while undergoing treatment, the weight is regained at an average rate of 0.8 kg per month once they quit.
"People buying these medications must be cognizant of the danger of rapid weight regain when the treatment concludes," stated expert Dr. Susan Jebb.
That rate of regain means a return to pre-treatment weight within about one and a half years.
Comparing Approaches
The research, which looked at dozens of studies involving thousands of patients, contrasted the outcomes of the injectable medications with other pills.
Scientists point out that individuals who lose weight through lifestyle changes alone usually experience a slower weight regain—perhaps 100 grams monthly—once they finish.
Understanding the Quick Rebound
Doctors suggest the way of the jabs is key to understanding the amplified rebound.
GLP-1 drugs copy a natural hormone called GLP-1, which helps regulate appetite.
"Sustained high doses of GLP-1 concentrations several times higher than the body's typical production could lead to the system to generate a reduced amount of its endogenous GLP-1, and could reduce sensitivity to its actions," said Dr. Adam Collins, a nutrition specialist.
"Withdrawal of this medication results in hunger is uncontrolled, making overeating a significant risk."
An Ongoing Disease?
The NHS suggest the jabs for individuals with obesity-related health risks, alongside recommended diet and exercise modifications.
Professionals say that, due to the high risk of relapse, the treatment should be considered ongoing.
This view is echoed by pharmaceutical companies, who say that the results "highlight the persistent nature of excess weight," similar to managing conditions like hypertension.
User Accounts
Users who have discontinued the jabs report a sudden resurgence of appetite.
"It felt as if something activating and you become extremely hungry," said one woman.
This challenge is worsened if individuals have not developed sustainable lifestyle or habit changes during treatment.
Widespread Interest
Survey data suggest that millions of adults in the UK have used weight-loss jabs in the last 12 months, with desire remaining high.
- Use is higher among women compared to men.
- The middle-aged age group shows the highest usage rates.
- Many obtain the drugs through private prescriptions rather than public health services.
Finally, clinicians stress that while GLP-1 drugs are powerful tools for shedding pounds, they are not a permanent cure and maintained weight loss likely depends on combined behavioural support.
